Yeast Therapy For the Treatment of Cancer and its Enhancement by MGN-3/Biobran, an Arabinoxylan Rice Bran PEER REVIEWED
- M. Ghoneum, J. Brown and S. Gollapudi
- (edited by Chris Gutch PhD.)
Apoptosis constitutes a strictly programmed device for the removal of aged, damaged and abnormal cells. Research in the last decade has revealed a promising future for apoptosis-based cancer therapies. However, chemotherapeutic agents exhibit an indiscriminative killing that involves both cancer cells and many normal cells. It is therefore of particular interest to find agents that have the ability to induce apoptotic activity specifically in cancer cells and with minimal side-effects. Interest in microbe-based approaches to cancer therapy has recently reemerged. The use of S. cerevisiae, the baker’s yeast, as a novel approach for the treatment of cancer is based on the concept that tumor cells undergo apoptosis upon phagocytosis of yeast. Our data shows that: 1) Heat killed yeast induces apoptosis in multiple human cancers [e.g. breast, tongue and colon] in vitro, 2) yeast has no toxicity against normal cells, 3) induction of apoptosis is yeast-specific, 4) apoptotic activity of yeast in cancer cells is enhanced by MGN-3/biobran, a biological response modifier, and importantly, 5) the phenomenon of yeast induced apoptosis was observed in vivo in athymic nude mice model. Electron microscopic studies of tissue samples obtained from in vivo yeast—treated tumors clearly show tumor cells phagocytize yeast and then undergo apoptosis. The molecular mechanism underlying this phenomenon is currently under investigtion in our laboratory. Further investigation into this area may present clinical implications for the treatment of cancer.
What are cookies?
Cookies are small text files which can be sent to browser when you visit websites and saved to your device (computer or other device with Internet access, i.e. smartphone or tablet). Cookies are saved in the folder for files of your browser. Cookies usually contain the name of the website they come from and the date of origin. Upon your next visit the browser loads cookies again and sends these information back to the website which originally created cookies. Cookies we use do not harm your computer.
By using this website you give your consent to using cookies in compliance with your browser settings. If you visit our websites, acceptance of cookies is allowed in your browser, you do not change your browser settings and continue visiting our websites we consider it as accepting our conditions for using cookies.
Why are we using cookies?
Cookies are used to optimally create and constantly improve the quality of our services, adjust them to your interests and needs and improve their structure and contents. We do not use data obtained by using cookies to contact users by mail, e-mail or telephone.
How to change settings of cookies?
Majority of browsers have been originally set to automatically accept cookies. This settings can be changed by blocking cookies or by a notification in case cookies are to be sent to your device. Instructions for changing cookies are available in the option “Help” of every browser. If you use different devices to access websites (e.g. computer, smartphone, tablet), we recommend you to adjust every browser on each of them to your preferences regarding cookies.
Why to keep settings of cookies?
Using cookies and permitting cookies in your browser is your decision. However, in case you change settings of cookies, functionality of some of our websites can be limited and their user comfort reduced.