MODIFIED RICE BRAN, MGN-3, IMPROVES GLUCOSE TORELANCE IN NIDDM ADULT RATS GIVEN STREPTOZOTOCIN AS NEONATES

  • Ohara I, Onai K, Maeda H
  • (edited by Chris Gutch PhD.)
  • 2002

The effect of modified rice bran (MGN-3) on glucose tolerance as studied in NIDDM adult rats and changes in taste preference were also examined. NIDDM adult rats were made by intraperitoneal injection of 100mg streptozotocin at 1.5 days of age. Following weaning, the animals were divided into 3 groups, control, diabetic rats fed 1% cellulose diet and diabetic rats fed 1% MGN-3 diet. Rats were free access to experimental diets and water for 2 months. Oral glucose tolerance tests were performed at 8 weeks of age. Two-bottle-choice preference tests between aqueous solution, either of 5mM citric acid, 0.016mM quinine sulfate, 0.82mM sodium saccharin, 21mM sodium chiloride or 27 mM monosodium glutamate, and deionized water were conducted in the experimental period. Trunk blood were collected and plasma levels of insulin, glucose, triglyceride, total cholesterol, HDL-cholesterol, Total protein, albumin, urea nitorogen and zinc were measured. Plasma glucose levels increased significantly faster and higher than that of the normal controls in oral glucose tolerance test. When the NIDDM rats administered MGN-3, the abrupt rise of plasma glucose levels slowed down. Although taste preferences in NIDDM rats were not significantly different as to the control, diabetic rats showed aversion to sourness as was observed in IDDM rats (Nutrition Research, in press). The plasma total cholesterol level only among various parameters lowered significantly by the administration of MGN-3. MGN-3 can be useful as a dietary fiber supplement for the treatment of diabetes

We use cookies to improve your experience on our website. For more details see our cookie policy.

Like many other websites, we use cookies to provide enhanced functionality and track the usage of our websites with Google Analytics, and some of our third-party advertisers might use them to deliver adverts tailored to what they think you might be interested in.

What are cookies?

Cookies are small text files which can be sent to browser when you visit websites and saved to your device (computer or other device with Internet access, i.e. smartphone or tablet). Cookies are saved in the folder for files of your browser. Cookies usually contain the name of the website they come from and the date of origin. Upon your next visit the browser loads cookies again and sends these information back to the website which originally created cookies. Cookies we use do not harm your computer.

Using cookies

By using this website you give your consent to using cookies in compliance with your browser settings. If you visit our websites, acceptance of cookies is allowed in your browser, you do not change your browser settings and continue visiting our websites we consider it as accepting our conditions for using cookies.

Why are we using cookies?

Cookies are used to optimally create and constantly improve the quality of our services, adjust them to your interests and needs and improve their structure and contents. We do not use data obtained by using cookies to contact users by mail, e-mail or telephone.

How to change settings of cookies?

Majority of browsers have been originally set to automatically accept cookies. This settings can be changed by blocking cookies or by a notification in case cookies are to be sent to your device. Instructions for changing cookies are available in the option “Help” of every browser. If you use different devices to access websites (e.g. computer, smartphone, tablet), we recommend you to adjust every browser on each of them to your preferences regarding cookies.

Why to keep settings of cookies?

Using cookies and permitting cookies in your browser is your decision. However, in case you change settings of cookies, functionality of some of our websites can be limited and their user comfort reduced.