| 1989 |
Mar |
A basic study
of activation of host defence mechanism by food:
paper by M. Yamazaki at the Faculty of Pharmaceutical
Science at Teikyo University. |
| 1992 |
Apr |
Active hemicellulous
compound (AHCC) enhance NK cell activity of aged mice
in vivo: presentation by M. Ghoneum at the
FASEB meeting in Anaheim, California. This compound
was developed by H. Maeda as a precursor to MGN-3. |
| |
Nov |
Enhancement
of human NK cell activity in vivo by AHCC:
presentation by M. Ghoneum at the 7th Annual Conference
on clinical Immunology in Philadelphia. |
| |
Nov |
Enhancement
of NK cell activity in cancer patients by AHCC:
presentation by M. Ghoneum at the Adjuvant Nutrition
in Cancer Treatment conference in Tulsa Oklahoma. |
| 1995 |
Mar |
H. Maeda successfully
develops commercially viable Biobran MGN-3 by using special extraction
methods on rice bran at Daiwa Pharmaceutical in Japan.
This proves much more potent than the AHCC he developed
a few years earlier. Clinical trials with this new
generation arabinoxylan compound begin. |
| |
Nov |
Immunomodulatory
and anti-cancer properties of MGN-3, a modified xylose
from rice bran, in 5 patients with breast cancer:
presentation by M. Ghoneum of UCLA/Drew University
at the American Association for Cancer Research at
Baltimore, Maryland, USA. NK cell activity substantially
increased within just a couple of weeks taking MGN-3
at a dose of 3g /day. Two patients who participated
early in the study (6-8 months) went into complete
remission. . |
| 1996 |
Apr |
NK immunomodulatory
function in 27 cancer patients by MGN-3, a modified
arabinoxylan from rice bran: presentation
by M. Ghoneum at the 87th Annual Meeting of the American
Association for Cancer research entitled. 7 patients
had breast cancer, prostate; 8 multiple myeloma (MM);
3 leukemia and 2 cervical. All patients taking conventional
treatments as well as 3g MGN-3 per day. All patients
had significant rises in NK cell activity when taking
MGN-3 (100 – 537% increases). |
| |
Apr |
Acute Oral Toxicity
Test at the AMA Laboratories, New York, USA
(Ref: WP96-BERN1/LD504881.DP) Animal Experiment involving
rats to determine any potential toxicity of MGN-3.
Above material can be classified as non-toxic according
to the reference. LD50 > 36.0g / kg. |
| |
Jun |
Effect of MGN-3
on human natural killer cell activity and interferon-g
synthesis in vitro: abstract of presentation
given by M. Ghoneum at the ASBMB/ASIP/AAI joint meeting
in New Orleans entitled. Conclusion was that MGN-3
is a potent Biological Response Modifier (BRM) as indicated
by the significant increases in human NK cell activity
at 16 hours post exposure through the production of
IFN-G. MGN-3 also had direct anti-cancer activity in
vitro. |
| |
Jul |
Anti-HIV activity
by MGN-3 in vitro: abstract of presentation
given by M. Ghoneum at the 11th International Conference
on AIDS in Vancouver. Conclusion: MGN-3 possesses a
potent effect against syncytia formation by HIV and
may be of potential value in therapy for HIV infection. |
| 1997 |
Sep |
The effect of
MGN-3, an arabinoxylan compound, on serum lipids in
streptozotocin induced diabetic rats: abstract
presented by Ohara, Tabuchi and Maeda (Japan) at the
38th Annual Meeting of The American College of Nutrition.
MGN-3 was shown to reduce the rise in serum triglyceride
and total cholesterol in diabetic rats indicating that
it may be useful in the treatment of diabetes. |
| 1998 |
Jan |
Anti-HIV activity
in vitro of MGN-3, an activated arabinoxylan from rice
bran: paper by M. Ghoneum in the Biochemical
and Biophysical Research Communications Journal 243,
25-29 (1998), Article No. RC978047. This is a detailed
write up of the abstract Ghoneum presented in July
1996 at the International Conference on AIDS in Vancouver. |
| |
Jan |
Enhancement
of human natural killer cell activity by modified arabinoxylan
from rice bran (MGN-3): paper by M. Ghoneum
in the International Journal of Immunotherapy XIV (2)
89-99 (1998). Study involved 24 individuals taking
MGN-3 at 3 different concentrations. NK cell activity
was significantly increased after 1 week and peaked
at 2 months. Also measured was a significant increase
in interferon-g. |
| |
Jun |
MGN-3 immunotherapy
for the treatment of cancer: abstract presented
by M. Ghoneum at the First International Symposium
on Disease Prevention by IP6 and Other Rice Components
in Japan. The 10 cancer patients in the study showed
large increases in NK cell activity and elevated T
and B cell function by its ability to produce cytokines
such as TNF-a and IFN-g. |
| |
Aug |
Synergistic effect of modified arabinosylan (MGN-3) and low dose of recombinant IL-2 human NK cell activity and TNF-α production: presentation by M. Ghoneum and A. Jewett at the Conference
of Anti-Aging Mechanism run by the American Academy of Anti-Aging Medicine in NJ. |
| |
Sep |
NK cell activity
by MGN-3: presentation by M. Ghoneum at the
26th Academy of Alternative Medicine of Cancer in Los
Angeles. |
| |
Oct |
Immunopotentiation
by utilization of MGN-3 tissue: presentation
by M. Ghoneum at the Congress on Anti-Aging Medicine
in Nevada. |
| |
Nov |
NK immunorestoration
of cancer patients by MGN-3, a modified arabinoxylan
rice bran (study of 32 patients up to 4 years):
paper by M. Ghoneum given at the 6th International
Congress on Anti-Aging & Bio-Medical Technologies.
Conclusion: MGN-3 is a potent biological response modifier
in its ability to significantly increasing the activity
of NK cells in both animals and humans. The mechanism
by which it does this is firstly that it increases
the granularity of the NK cells and secondly it elevates
cytokine production. |
| |
Dec |
Active oxygen radical scavenging activity of the plant polysaccharide processed foodstuff Biobran: presentation
by K. Tazawa, Toyama Medical and Pharmaceutical University,
and H. Maeda, Daiwa Pharmaceutical Co. Ltd., at the
3rd JsoFF Conference. |
| 1999 |
Jul |
A case study
of supplementary application of rice bran Arabinoxylan
(MGN-3) to bone metastasis from lung cancer:
presentation by T. Sobajima and H. Maeda at the 2nd
Conference of Japanese Association for Alternative,
Complementary and Traditional Medicine (JACT), Tokyo
Japan. Sobajima T., Hoshigaoka Welfare Annuity Hospital
and Maeda H., Daiwa Pharmaceutical Co. Ltd., Tokyo. |
| |
Jul |
Evaluation of
MGN-3 (Biobran) on superoxide scavenging activity:
presentation by K. Tazawa, H. Namikawa, S. Oida, K.
Ito, M. Yatsuzuka, J. Koike, H. Maeda at the 6th Japanese
Conference on Cancer Prevention, Tokyo Japan. Toyama
Medical University. |
| |
Sep |
Modified rice bran improves glucose tolerance in NIDDM adult rats given streptozocin as neonates: presentation by Ohara I., Onai K. (Kobe Women's University) and Maeda H. (Daiwa) at the 40th meeting of the American College of Nutrition in Washington DC. |
| |
Dec |
Evaluation of
MGN-3 (Biobran) with activation function of NK cell
activity on superoxide scavenging activity:
presentation by K. Tazawa, H. Namikawa, S. Oida, K.
Ito, M. Yatsuzuka, J. Koike, M. Masada and H. Maeda
at the 12th Japanese Conference on Bio Therapy, Yokohama
Japan. Toyama Medical University, Chiba University
and Daiwa Pharmaceutical. |
| |
Dec |
Application
of modified rice bran dietary fiber to diabetes and
taste preference in streptozotocin-included diabetic
rats: presentation by I. Ohara, K. Onai and
H. Maeda at the 2nd International Conference on Food
Factors, Kyoto, Japan. Laboratory of Nutrition, Kobe
Women's University, and Daiwa Pharmaceutical. |
| |
Dec |
Immunostimulation
and Cancer Prevention: presentation by M.
Ghoneum at the 7th International Congress on Anti-Aging & Biomedical
Technologies, Las Vegas, USA. Drew University. |
| 2000 |
Jan |
Physiological
Activator, Oryza Sativa L. Arabinoxylan Derivative
(MGN-3): presentation by H. Maeda at the 6th
Japanese Congress on Mibyo System, Hiroshima Japan.
Daiwa Pharmaceutical Co. Ltd. |
| |
Jan |
Production of
TNF-a and IFN-g From human peripheral blood lymphocytes
by MGN-3, a modified arabinoxylan from rice bran:
paper by Ghoneum and Jewett in Cancer Detection and
Prevention, 24 (4): 314-324 (2000). This study showed
that MGN-3 is a potent TNF-a producer and that it induces
the TNF-a secretion in a dose dependent manner. Also,
a combination of MGN-3 and IL-2 resulted in a synergistic
induction of TNF-a and IFN-g secretion. MGN-3 appears
to increase the expression of CD69 activation antigen. |
| |
Jan |
Effects of modified
rice bran on serum lipids and taste preference in streptozotocin-induced
diabetic rats: paper by Ohara, Agr, Tabuchi,
Onai and Econ from Kobe Women's University in
Kobe Japan in the Journal Of Nutritional Research,
Vol. 20, No. 1, pp.59-68, 2000. The study was to determine
whether the administration of MGN-3 could improve streptozotocin-induced
diabetes. Results: serum triglycerides and total cholesterol
decreased, and polyuria and taste was improved. |
| |
Jun |
The Effect of
MGN-3 on cisplatin and adriamycin induced toxicity
in the rat: paper by Jacoby, Wnorowski, Sakata
and Maeda published in the American Society for Pharmacology
and Experimental Therapeutics, Boston, USA. Conclusion:
MGN-3 protects rates given an acutely toxic dose of
cisplatin or adriamcyin. This indicates that the MGN-3
may well be good at improving the quality of life in
patients receiving chemotherapy and may be a useful
adjunct, therefore, to cancer chemotherapy. Product
Safety Lab. and Daiwa Pharmaceutical Co. Ltd. |
| |
Oct |
Inhibitory effects
of MGN-3 (modified Arabinoxylan from rice bran) on
free radical: presentation by T. Saito, H.
Ohkami, K. Tsukada, K. Tazawa, H. Namikawa, S. Oida,
J. Koike, M. Yatsuzuka, M. Masada, and H. Maeda at
the 59th Annual Meeting of the Japanese Cancer Association,
Yokohama Japan. Toyama Medical University, Chiba University
and Daiwa Pharmaceutical. |
| |
Nov |
Evaluation of
immune (arabinoxylan) therapy seen from NK cell activity
and the CD4/CD8 ration
on cancer patients: The 3rd Annual Meeting of
the Japanese Society for Complementary & Alternative Medicine
& Treatment,
Tokyo, Japan. |
| |
Dec |
Natural biological
response modifier (MGN-3) shown to be effective against
tumor cell growth: presentation by M. Ghoneum,
K. Tachiki, K. Ueyama, T. Makinodan, N. Makhijani and
D. Yamaguchi at the 8th International Congress on Anti-Aging & Biomedical
Technologies, December 14-17, 2000, Las Vegas, NV. |
| 2001 |
Jan |
Application
of the alterantive medicine of a new physiological
active substance "arabinoxylan derivative"
(MGN-3, Biobran): 7th Conference of Japan Mibyou
System Association, Nagoya, Japan. Maeda H., Daiwa Pharmaceutical
Co. Ltd. |
| |
Mar |
MGN-3, a novel
antitumor agent: presentation by K. Uyemura,
K. Tachiki, M. Ghoneum, T. Makinodan, N. Makhijani
and D. Yamaguchi at the 92nd Annual Meeting, American
Association for Cancer Research. The research team
found that MGN-3 not only increased NK cell activity,
but also the production and secretion of cytokines
such as IL-10 and IL-12 by cancer cells such as MCF-7.
Treatment of cultures of MCF-7 cells with MGN-3 also
can arrest cell growth. |
| |
Jul |
Inhibitory effect
of MGN-3 on the progress of atopic dermatitis in NC
mice: presentation by S. Nonoyama and L. Lin
at 11th International Congress of Immunology and written
up in the Scandinavian Journal of Immunology — Volume
54, Supplement 1, July / August 2001. |
| |
Nov |
A Descriptive
Questionnaire-Based Study on the Use of Biobran (MGN-3)
in Chronic Fatigue Syndrome: study by Dr.
J. Kenyon published in the Townsend Letter, November
2001. |
| 2002 |
Mar |
Study on the
growth inhibiting component of cancerous cells in culture
cell lines derived from modified rice-bran arabinoxylan: paper
presented at the 46th Japan Society for Bioscience,
Biotechnology and Agrochemistry by Miyazaki F., Hashizume
T., Kodama H., Maeda H. and M. Masada. Technology Department,
Kazami Co., Ltd.,Department of Biresources Chemistry,
Faculty of Horticulautre, Chiba University and Daiwa
Pharmaceutical Co., Ltd. |
| |
Mar |
Effects of modified
rice-bran arabinoxylan on NK activity of human peripheral
blood lymphocytes: paper presented at the
46th Japan Society for Bioscience, Biotechnology and
Agrochemistry, Sendai, Japan by Shimomura C., Ueda
Y., Kodama H., Maeda H. and M. Masada, Department of
Bioresources Chemistry, Faculty of Horticulture, Chiba
University and Daiwa Pharmaceutical Co., Ltd. |
| |
May |
Effects of rice
bran arabinoxylan on induced hepatitis in rats (in
Japanese): paper by Maeda H. et al. published in the
Journal of Japanese Association for Dietary Fiber Research
(Vol 6, No 2) |
| |
Oct |
Normalization
of the lymphocyte system in peripheric blood reaction
by arabinoxylan from rice bran (MGN-3): paper
presented at the 43rd Annual Meeting at the American
Clooege of Nutrition, San Antonio, Texas, by Ueda Y.,
Masada M. and H. Maeda. Department of Bioresources
Chemistry, Faculty of Horticulature, Chiba University
and Daiwa Pharmaceutical Co. Ltd. |
| |
Oct |
MGN-3 potentiates
death receptor-induced apoptosis in cancer cells:
paper presented at the 93rd Annual Meeting 2003 of
American Association for Cancer Research, Boston, USA
by M. Ghoneum and S. Gollapudi, Drew University of
Medicine and Science, Los Angeles, CA, UC Irvine, Division
of Basic and Clinical Immunology, Irvine CA. |
| |
Oct |
A basic study
on protective effects of Biobran against myelogenetic
death by radiation exposure: paper
by Dr. S. Nakatugawa of Nagoya University Medical School
Hospital in Japan given at the American Association
for Cancer Research meeting in Boston, MA. |
| |
Oct |
Modified rice
bran beneficial for adverse effect of cisplatin to
prevent weigth loss of mice: paper
by Yuzo Endo and Hiroshi Kanbayashi from McMaster University
in Ontario Canada given at the American Association for
Cancer Research meeting in Boston, MA (also published in
Pharmacology and Toxicology). |
| |
Nov |
Effect of enzyme-processed
rice bran hemicellulose (MGN-3) on experimental liver
dysfunction
in rats: paper presented at the 7th Conference of Japanese
Association for Dietary Fiber Research, Tokyo, Japan by
Yamada T., Daizou A., Poindoglun K., Egashira K., Maeda
H. and Sanada H. Graduate School of Science and Technology,
Chiba University, Department of Bioresources Chemistry,
Chiba University and Daiwa Pharmaceutical Co. Ltd. |
| |
Nov |
Significant
of sthmatic mouse model exposed to antigen (Toluene
Diisocyanate) for a prolonged
period: paper presented at the 52nd Conference of Japanese
Society of Allergology, Yokohama, Japan by Kanbayshi H.
and Y. Endo, Department of Pathological Molecular Medicine,
McMaster University. |
| |
Nov |
Evaluation of
the effects of asthma prevention and symptom reduction
by enzymatically modified rice-bran foods in asthmatic
model mice:
paper presented at the 52nd Conference of Japanese
Society of Allergology, Jokohama, Japan by Kanbayashi
H. and Endo Y., Department of Pathological Molecular
Medicine, McMaster University. |
| 2003 |
Sept |
Effect of Biobran
proved by Scientific Studies: Japanese Academy for Clinical Complementary &
Alternative Medicine, Maeda H., Daiwa Pharmaceutical Co.
Ltd. |
| |
Oct |
A novel approach to breast cancer therapy: modified arabinoxylan rice bran (MGN-3/Biobran) enhances apoptosis of human breast cancer cells following phagocytosis of saccharomyces cerevisiae, the baker's yest, in vitro: presentation by Ghoneum M. (UCLA) and Gollapudi S. (University of California Irvine) at The Japanese Society for Complementary and Alternative Medicine, Sendai American Association for Cancer Research Speicial Conference in California. |
| |
Oct |
Immunoactivation
therapy for various prograssive cancers using rice
bran arabinoxylan derivative
(Biobran): The Japanese Society for Complementary and Alternative
Medicine, Tsunekawa H. and Maeda H. |
| |
Nov |
Modified arabinoxylan
rice bran (MGN-3 /Biobran) sensitizes human T cell leukemia
cells to death receptor (CD95)-induced apoptosis: paper
by Mamdooh Ghoneum and Sastry Gollapudi published in
Cancer Letters 201 (2003) 41-49 / Elsevier. |
| |
Dec |
The oral administration
of the hydrolysis rice bran prevents a common cold
syndrom for elderly perople
based on immunomodulatory function: Medical and Pharmaceutical
Society for Wakan Yaku, Maeda H., Omura K. and Zhu K.,
Daiwa Pharmaceutical Co. Ltd. |
| |
Dec |
The effect in the physiological function of a modified arabinoxylan rice bran: Japan Society for Biological Therapy, Masada M., Maeda H. and Tazawa K., Chiba University, Daiwa Pharmaceutical Co. Ltd., Toyama Medical University. |
| |
Dec |
Effect of rice bran arabinosylan and shark lipid extract on complementary and alternative therapy: paper presented by Omori T. (Ginza San Espero Omori Clinic) at the 7th Conference of the Japanese Assoc. for Alternative, Complementary and Traditional Medicine (JACT) at Kobe. |
| 2004 |
Feb |
Modified arabinoxylan rice bran (MGN-3 /Biobran) potentiates apoptosis in cancer cells induced by multiple anti-cancer agents in vitro: paper presented by Ghoneum M. and Gollapudi S. at the 7th International Symposium on Predictive Oncology & intervention Strategies in Nice. |
| |
May |
The Clinical Significance of Biobran in the Immunotherapy for Cancer: paper by Yasushi Okamura, Director of the Insitute of Life Science, Japan, published in Clinical Pharmacology and Therapy Vol. 14/No.3 |
| |
May |
One Case of a Patient with Umbilical Metastasis of Recurrental Cancer (Sister Mary Joseph's Nodule, SMJN) Who has Survived for a Long Time under Immunomodulatory Supplement Therapy: paper by Tomonori Kawai, Shinkurashiki icho komon geka, published in Clinical Pharmacology and Therapy Vol. 14/No.3 |
| |
May |
The Life Prolongation and QOL Improvement Effect of Rice Bran Arabinoxylan Derivative (MGN-3, Biobran) for Progressive Cancer: paper by Kihachiro Takahara and Kamataro Sano, Sano Surgery Clinic, published in Clinical Pharmacology and Therapy Vol. 14/No.3 |
| |
May |
Effect of Long-term Administration of Immunomodulatory Food on Cancer Patients Completing Conventional Treatments: paper by Hiroshi Tsunekawa, Tsunekawa Gastrointestinal Clinic, published in Clinical Pharmacology and Therapy Vol. 14/No.3 |
| |
May |
A Case Where an Immunomodulatory Food was Effective in Conservative Therapy for Progressive Terminal Pancreatic Cancer: paper by Kazutoshi Kaketani, Hanzomon Gastrointestinal Clinic, published in Clinical Pharmacology and Therapy Vol. 14/No.3 |
| |
Jun |
Effect of the oral administration of hydrolyzed rice bran (HRB) on the common cold syndrome of the elderly: paper presented by Omura K. (Dokkyo University School of Medicine), Ichihashi K. (Ichihashi Clinic), Maeda H. (Daiwa Pharmaceutical) and Tazawa K. (Toyama Medical and Pharmaceutical University) at the 4th Conference of the Japanese Society of Anti-Aging Medicine in Tokyo. |
| |
Aug |
Repeat presentation of the above paper at the 21st Symposium of Medical and Pharmaceutical Society for Wakan-Yaku. |
| |
Aug |
Evaluation of the effect of hyrolyzed rice bran on reducing respiratory symptoms in smokers: paper by Kudo M., Maeda H. (Daiwa) and Nakamichi N. (Jikei University, N.S. Clinic) at the 21st Symposium of Medical and Pharmaceutical Society for Wakan-Yaku. |
| |
Sep |
Chemical structure of immunostimulating substances from rice bran: paper presented by Miura T., Chiba M., Miyazaki Y., Kato Y. (Hirosaki University) and Maeda H. (Daiwa Pharmaceutical) at the 2004 Annual Meeting of the Japanese Society of Applied Glycoscience and the 12th Symposium on Amylases and Related Enzymes, Kagoshima. |
| |
Sep |
Hyrolyzed rice bran reduces the aggravation of protein metabolism in streptozotocin-induced diabetic rats: paper by Kitamura N., Ohara I., (Aichi Gakusen University) and Maeda H. (Daiwa Pharmaceutical) at the 45th Annual Meeting of the American College of Nutrition in California. |
| |
Sept |
Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3 /Biobran): paper by M. Ghoneum and S. Abedi in the Journal of Pharmacy and Pharmacology (56: 1581-1588). |
| |
Oct |
Induction of apoptosis in breat cancer cells by Saccharomyces Cerevisiae, the Baker's Yeast, in vitro: paper by M. Ghoneum and S. Gollapudi in Anticancer Research vol 24: 1455-1464. |
| 2005 |
Nov |
Modified Arabinoxylan Rice Bran (MGN-3/Biobran) Enhances Yeast-induced Apoptosis in Human Breast Cancer Cells In Vitro: paper by M. Ghoneum and S. Gollapudi in Anticancer Research vol 25: 859-870 |
| |
Nov |
Human Squamous Cell Carcinoma of the Tongue and Colon Undergoes Apoptosis upon Phagocytosis of Saccharomyces Cerevisiae, the Baker's Yeast, In Vitro: paper by M. Ghoneum, J. Hamilton, J. Brown, S. Gollapudi in Anticancer Research vol 25: 981-990 |
| |
Nov |
Synergistic Role of Arabinoxylan Rice Bran (MGN-3/Biobran) in S. cerevisiae-induced Apoptosis of Monolayer Breast Cancer MCF-7 Cells: paper by M. Ghoneum and S. Gollapudi in Anticancer Research vol25: 4187-4196 |
| |
Dec |
A case where immunomodularity food and anti-oxidant therapy ws effective in a case of advanced prostate cancer: report by Dr. Serge Jurasunas of the Holiterapias Institute in Portugal. |
| 2006 |
Jun |
Hepatic Impairment Inhibiting Effect of Biobran: an interview of Dr. Hiroo Sanada of Chiba Univerity in Japan. |
